Saliva of blood-feeding arthropods induces in their hosts an antibody response which may be used as indicator of human exposure to disease vectors. We have recently shown that the Anopheles gambiae gSG6 (gambiae Salivary Gland protein 6) is a good candidate as marker of exposure to African malaria vectors, suggesting it may represent a useful epidemiological tool both for the evaluation of malaria transmission/risk and for monitoring vector control measures. We present here the identification of a novel, anopheline-specific, immunogenic salivary protein and provide evidence that distinct components of mosquito saliva may induce differential humoral response in individuals from malaria endemic areas. Implications for malaria control and epidemiology will be discussed.
Anopheles salivary antigens as markers of human exposure to malaria vectors / Arca', Bruno. - STAMPA. - (2012), pp. 2-2. (Intervento presentato al convegno IV Annual Meeting COST Action BM0802 Life or Death of Protozoan Parasites – V Annual meeting Italian Malaria Network (IMN) CIRM-Centro Universitario Ricerca sulla Malaria tenutosi a Milano (Italy) nel 19-21 Gennaio 2012).
Anopheles salivary antigens as markers of human exposure to malaria vectors.
ARCA', Bruno
2012
Abstract
Saliva of blood-feeding arthropods induces in their hosts an antibody response which may be used as indicator of human exposure to disease vectors. We have recently shown that the Anopheles gambiae gSG6 (gambiae Salivary Gland protein 6) is a good candidate as marker of exposure to African malaria vectors, suggesting it may represent a useful epidemiological tool both for the evaluation of malaria transmission/risk and for monitoring vector control measures. We present here the identification of a novel, anopheline-specific, immunogenic salivary protein and provide evidence that distinct components of mosquito saliva may induce differential humoral response in individuals from malaria endemic areas. Implications for malaria control and epidemiology will be discussed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
