The (-)- and (+)-isomers of the cis- and trans-Ph/Me 1-(1-Phenyl-2-methylcyclohexyl)piperidines have been sinthesized and the achiral cis- and trans-Ph/Me 1-(1-Phenyl-4-methylcyclohexyl)piperidines were prepared, and their in vitro and in vivo activities determined.
Synthesis, Stereochemistry, and Biological Activity of the 1-(1-Phenyl-2-methylcyclohexyl)piperidines and the 1-(1-Phenyl-4-methylcyclohexyl)piperidines. Absolute Configuration of the Potent trans-(-)-1-(1-Phenyl-2-methylcyclohexyl)piperidine / M. A., Iorio; Tomassini, Lamberto; M. V., Mattson; C., George; A. E., Jacobson. - In: JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0022-2623. - STAMPA. - 34:(1991), pp. 2615-2623.
Synthesis, Stereochemistry, and Biological Activity of the 1-(1-Phenyl-2-methylcyclohexyl)piperidines and the 1-(1-Phenyl-4-methylcyclohexyl)piperidines. Absolute Configuration of the Potent trans-(-)-1-(1-Phenyl-2-methylcyclohexyl)piperidine.
TOMASSINI, Lamberto;
1991
Abstract
The (-)- and (+)-isomers of the cis- and trans-Ph/Me 1-(1-Phenyl-2-methylcyclohexyl)piperidines have been sinthesized and the achiral cis- and trans-Ph/Me 1-(1-Phenyl-4-methylcyclohexyl)piperidines were prepared, and their in vitro and in vivo activities determined.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
