A two-phase model for diffusion and drug release through swollen polymeric matrices is presented and solved. This model explains the non-Fickian release behaviour experimentally found for the system constituted by theophylline in a water-swollen scleroglucan matrix in a slab form. The exponential nature of the temporal behaviour of the drug in the stationary phase is confirmed by means of Green function analysis. The boundary conditions deriving from the non-self-sustaining nature of the polymeric gel and from the presence of a net are investigated in detail.
Controlled release of theophylline from water-swollen scleroglucan matrices / Adrover, Alessandra; Giona, Massimiliano; Mario, Grassi; Romano, Lapasin; Sabrina, Pricl. - In: JOURNAL OF MEMBRANE SCIENCE. - ISSN 0376-7388. - STAMPA. - 113:1(1996), pp. 7-20. (Intervento presentato al convegno 7th International Symposium on Synthetic Membranes in Science and Industry tenutosi a TUBINGEN, GERMANY nel AUG 29-SEP 01, 1994) [10.1016/0376-7388(95)00289-8].
Controlled release of theophylline from water-swollen scleroglucan matrices
ADROVER, Alessandra;GIONA, Massimiliano;
1996
Abstract
A two-phase model for diffusion and drug release through swollen polymeric matrices is presented and solved. This model explains the non-Fickian release behaviour experimentally found for the system constituted by theophylline in a water-swollen scleroglucan matrix in a slab form. The exponential nature of the temporal behaviour of the drug in the stationary phase is confirmed by means of Green function analysis. The boundary conditions deriving from the non-self-sustaining nature of the polymeric gel and from the presence of a net are investigated in detail.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
