In an asymptomatic 4 yr old child with radiographic evidence of parenchymal lung disease, bronchoalveolar lavage (BAL) yielded the diagnosis of chronic lipid pneumonia caused by chronic aspiration of mineral oil given as a laxative. BAL analysis showed a marked reduction in the total number of alveolar macrophages; almost 70% of these cells contained intracytoplasmic lipid vacuoles. It also disclosed lymphocytic (cytotoxic/suppressor) alveolitis. A high percentage of lymphocytes expressed antigen markers of activation (human leucocyte antigen (HLA)-DR), CD54 and CD25). BAL analysis 18 months after mineral oil intake revealed that lymphocytes bearing antigen markers of activation had markedly decreased whereas alveolar macrophages (normal and lipid-laden) had increased. A subsequent whole lung BAL was considered unnecessarily invasive in this otherwise healthy child.
Bronchoalveolar lavage cell analysis in a child with chronic lipid pneumonia / Midulla, Fabio; Strappini, Pier Michele; Ascoli, Valeria; Villa, MARIA PIA; Indinnimeo, Luciana; C., Falasca; S., Martella; Ronchetti, Roberto. - In: EUROPEAN RESPIRATORY JOURNAL. - ISSN 0903-1936. - ELETTRONICO. - 11:1(1998), pp. 239-242. [10.1183/09031936.98.11010239]
Bronchoalveolar lavage cell analysis in a child with chronic lipid pneumonia
MIDULLA, Fabio;STRAPPINI, Pier Michele;ASCOLI, Valeria;VILLA, MARIA PIA;INDINNIMEO, Luciana;RONCHETTI, ROBERTO
1998
Abstract
In an asymptomatic 4 yr old child with radiographic evidence of parenchymal lung disease, bronchoalveolar lavage (BAL) yielded the diagnosis of chronic lipid pneumonia caused by chronic aspiration of mineral oil given as a laxative. BAL analysis showed a marked reduction in the total number of alveolar macrophages; almost 70% of these cells contained intracytoplasmic lipid vacuoles. It also disclosed lymphocytic (cytotoxic/suppressor) alveolitis. A high percentage of lymphocytes expressed antigen markers of activation (human leucocyte antigen (HLA)-DR), CD54 and CD25). BAL analysis 18 months after mineral oil intake revealed that lymphocytes bearing antigen markers of activation had markedly decreased whereas alveolar macrophages (normal and lipid-laden) had increased. A subsequent whole lung BAL was considered unnecessarily invasive in this otherwise healthy child.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.