Purpose: We address whether rational and significant clinical data exist on using angiogenic targeted therapies as neoadjuvant or adjuvant options to nephrectomy in non-metastatic RCC. Methods: We reviewed the recent international literature by carrying out a PUBMED search. Results: Neoadjuvant: a possible indication for a neoadjuvant targeted therapy approach is to facilitate surgery, reducing risks for patients and increasing the possibility of removing the mass and improving oncological results. Adjuvant: three major phase III clinical trials are currently ongoing. The ASSURE trial (1 year on oral sunitinib, sorafenib or placebo), the SORCE trial (3 years on placebo versus 1 year on sorafenib, followed by 2 years on placebo versus 3 years on sorafenib), and the S-TRAC trial (1 year on sunitinib or placebo) analyze patients who are at high risk of relapse. Conclusions: Rationale and needs for the neoadjuvant or adjuvant use of targeted therapies in RCC are relevant. Significant phase III trials on the adjuvant use of targeted therapy in RCC are ongoing. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

The emerging role of targeted therapy in renal cell carcinoma (RCC): Is it time for a neoadjuvant or an adjuvant approach? / Sciarra, Alessandro; Cattarino, Susanna; Salciccia, Stefano; Alfarone, Andrea; Gentilucci, Alessandro; Parente, Ulderico; Gianna, Mariotti; Innocenzi, Michele; Gentile, Vincenzo. - In: CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY. - ISSN 1040-8428. - STAMPA. - 81:2(2012), pp. 151-162. [10.1016/j.critrevonc.2011.02.003]

The emerging role of targeted therapy in renal cell carcinoma (RCC): Is it time for a neoadjuvant or an adjuvant approach?

SCIARRA, Alessandro;CATTARINO, SUSANNA;SALCICCIA, STEFANO;ALFARONE, ANDREA;GENTILUCCI, ALESSANDRO;PARENTE, ULDERICO;INNOCENZI, MICHELE;GENTILE, Vincenzo
2012

Abstract

Purpose: We address whether rational and significant clinical data exist on using angiogenic targeted therapies as neoadjuvant or adjuvant options to nephrectomy in non-metastatic RCC. Methods: We reviewed the recent international literature by carrying out a PUBMED search. Results: Neoadjuvant: a possible indication for a neoadjuvant targeted therapy approach is to facilitate surgery, reducing risks for patients and increasing the possibility of removing the mass and improving oncological results. Adjuvant: three major phase III clinical trials are currently ongoing. The ASSURE trial (1 year on oral sunitinib, sorafenib or placebo), the SORCE trial (3 years on placebo versus 1 year on sorafenib, followed by 2 years on placebo versus 3 years on sorafenib), and the S-TRAC trial (1 year on sunitinib or placebo) analyze patients who are at high risk of relapse. Conclusions: Rationale and needs for the neoadjuvant or adjuvant use of targeted therapies in RCC are relevant. Significant phase III trials on the adjuvant use of targeted therapy in RCC are ongoing. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
2012
nephrectomy; renal cell carcinoma; sorafenib; targeted therapy
01 Pubblicazione su rivista::01a Articolo in rivista
The emerging role of targeted therapy in renal cell carcinoma (RCC): Is it time for a neoadjuvant or an adjuvant approach? / Sciarra, Alessandro; Cattarino, Susanna; Salciccia, Stefano; Alfarone, Andrea; Gentilucci, Alessandro; Parente, Ulderico; Gianna, Mariotti; Innocenzi, Michele; Gentile, Vincenzo. - In: CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY. - ISSN 1040-8428. - STAMPA. - 81:2(2012), pp. 151-162. [10.1016/j.critrevonc.2011.02.003]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/480112
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