The heart rate corrected QT interval (QTc) and plasma catecholamine (CA) and norepinephrine (NE) levels were measured in 15 symptomatic patients with idiopathic mitral valve prolapse (MVP) and in 19 control subjects. MVP patients showed longer mean QTc and were divided into two groups: group A normal QTc (> 440 msec) and group B prolonged QTc (< 440 msec). In supine resting conditions CA levels were as follows: group A 0.420 ± 0.035 ng/ml and group B 0.619 ± 0.104 ng/ml (p < 0.05); both were greater than control values (0.348 ± 0.017 ng/ml, p < 0.005). NE levels were as follows: group A 0.350 ± 0.031 ng/ml and group B 0.376 ± 0.052 ng/ml (NS); both were greater than control values (0.242 ± 0.025 ng/ml, (p < 0.05). When a standing position was assumed, CA and NE levels increased significantly in all groups but this was most marked in group B as compared to control levels (CA: 1.039 ± 0.123 ng/ml versus 0.625 ± 0.037 ng/ml; NE: 0.737 ± 0.076 ng/ml versus 0.504 ± 0.031 ng/ml) (p < 0.001 and p < 0.05, respectively). Thus the longest QTc was observed in patients with MVP who had the highest levels of CA and NE, in both supine and standing positions. These data may account, in part, for the occurrence of severe ventricular arrhythmias in some patients with MVP and may offer a rationale for adrenergic blockade in that subset of patients with MVP and markedly prolonged QTc. © 1983.

QT interval prolongation and increased plasma catecholamine levels in patients with mitral valve prolapse / Puddu, Paolo Emilio; A., Pasternac; J. F., Tubau; R., Krol; L., Farley; J. D., Champlain. - In: AMERICAN HEART JOURNAL. - ISSN 0002-8703. - 105:3(1983), pp. 422-428.

QT interval prolongation and increased plasma catecholamine levels in patients with mitral valve prolapse

PUDDU, Paolo Emilio;
1983

Abstract

The heart rate corrected QT interval (QTc) and plasma catecholamine (CA) and norepinephrine (NE) levels were measured in 15 symptomatic patients with idiopathic mitral valve prolapse (MVP) and in 19 control subjects. MVP patients showed longer mean QTc and were divided into two groups: group A normal QTc (> 440 msec) and group B prolonged QTc (< 440 msec). In supine resting conditions CA levels were as follows: group A 0.420 ± 0.035 ng/ml and group B 0.619 ± 0.104 ng/ml (p < 0.05); both were greater than control values (0.348 ± 0.017 ng/ml, p < 0.005). NE levels were as follows: group A 0.350 ± 0.031 ng/ml and group B 0.376 ± 0.052 ng/ml (NS); both were greater than control values (0.242 ± 0.025 ng/ml, (p < 0.05). When a standing position was assumed, CA and NE levels increased significantly in all groups but this was most marked in group B as compared to control levels (CA: 1.039 ± 0.123 ng/ml versus 0.625 ± 0.037 ng/ml; NE: 0.737 ± 0.076 ng/ml versus 0.504 ± 0.031 ng/ml) (p < 0.001 and p < 0.05, respectively). Thus the longest QTc was observed in patients with MVP who had the highest levels of CA and NE, in both supine and standing positions. These data may account, in part, for the occurrence of severe ventricular arrhythmias in some patients with MVP and may offer a rationale for adrenergic blockade in that subset of patients with MVP and markedly prolonged QTc. © 1983.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/479590
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