The fundamental role of antibodies in the development of acute graft rejection has been established recently. Antibody-mediated acute rejection may develop at any time during the post-transplant period. Several therapeutic approaches have been proposed in the last decades. However, there is no standardized therapy. The aim of this study is to report the Sapienza University experience of combined plasma treatment and high-dose intravenous immunoglobulin ± extracorporeal photopheresis. From January 2006 to September 2009, 6 patients were treated at Sapienza University. In 5 cases (83%) complete regression of the acute rejection was observed, followed by stable renal function (median creatinine value at 1-year follow-up: 1.5 mg/dL). No adverse events were reported. Our approach seems to give good results in terms of graft survival and procedure safety. Further studies on a larger number of patients will be needed to confirm the validity of these findings. Moreover, comparison between our protocol and other treatments is necessary.

[Multimodal treatment for acute antibody-mediated renal transplant rejection: successful rescue therapy with combined plasmapheresis, photopheresis and intravenous immunoglobulin] / Lai, Quirino; Pretagostini, Renzo; M., Gozzer; Cinti, Paola; Meo, Donatella; Vita, Fabiana; M. S., Bafti; Poli, Luca; Novelli, Gilnardo; Rossi, Massimo; Girelli, Gabriella; Berloco, Pasquale Bartolomeo. - In: GIORNALE ITALIANO DI NEFROLOGIA. - ISSN 0393-5590. - STAMPA. - 29:Suppl 54(2012), pp. S31-S35.

[Multimodal treatment for acute antibody-mediated renal transplant rejection: successful rescue therapy with combined plasmapheresis, photopheresis and intravenous immunoglobulin].

LAI, QUIRINO;PRETAGOSTINI, Renzo;CINTI, Paola;MEO, DONATELLA;VITA, FABIANA;POLI, Luca;NOVELLI, Gilnardo;ROSSI, MASSIMO;GIRELLI, Gabriella;BERLOCO, Pasquale Bartolomeo
2012

Abstract

The fundamental role of antibodies in the development of acute graft rejection has been established recently. Antibody-mediated acute rejection may develop at any time during the post-transplant period. Several therapeutic approaches have been proposed in the last decades. However, there is no standardized therapy. The aim of this study is to report the Sapienza University experience of combined plasma treatment and high-dose intravenous immunoglobulin ± extracorporeal photopheresis. From January 2006 to September 2009, 6 patients were treated at Sapienza University. In 5 cases (83%) complete regression of the acute rejection was observed, followed by stable renal function (median creatinine value at 1-year follow-up: 1.5 mg/dL). No adverse events were reported. Our approach seems to give good results in terms of graft survival and procedure safety. Further studies on a larger number of patients will be needed to confirm the validity of these findings. Moreover, comparison between our protocol and other treatments is necessary.
2012
01 Pubblicazione su rivista::01a Articolo in rivista
[Multimodal treatment for acute antibody-mediated renal transplant rejection: successful rescue therapy with combined plasmapheresis, photopheresis and intravenous immunoglobulin] / Lai, Quirino; Pretagostini, Renzo; M., Gozzer; Cinti, Paola; Meo, Donatella; Vita, Fabiana; M. S., Bafti; Poli, Luca; Novelli, Gilnardo; Rossi, Massimo; Girelli, Gabriella; Berloco, Pasquale Bartolomeo. - In: GIORNALE ITALIANO DI NEFROLOGIA. - ISSN 0393-5590. - STAMPA. - 29:Suppl 54(2012), pp. S31-S35.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/479493
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