CD44v6 and Nm 23-H1 protein expression related to clinico pathological parameters in colorectal cancer.

Nm23-H1 and CD44v6 expression has been shown to be correlated with the metastatic potential oJ colorectal cancer (CRC) in some studies but not in others. The present study was undertaken to evaluate immunohistochemically the expression oJ these markers and to correlate themwith clinicopathological variabLes. Matherials and Methods: Archival tissues oJ 41 non metastatic colorectal cancers were histopathologically evaluated and stained with monoclonal antibodies versus Nm23-HI and CD44v6. Results: Expression oJ Nm23-H1 uras detected in 73% (n=30) o/ alI CRe, and CD44v6 in 37% (n=I5) o/ alI CRe CD44v6 was found to be statistically àssociatedwith tumour grading di.lferentiation (p<O. 03), but no correlation emerged between Nm23-H1 and CD44v6 and Dukes stage, site, peritumoral !l,mphocytic injìltration, venous injìltrating, perineural inJzltrating, tumour budding, pushing and injìltrating tumour growth. Conclusion: Even if the results are not statistically significant, tne authors noticed that the expression o/ Nm23-HI was correlated with those histopathological parameters that indicate local disease progression and metastases.