Triclosan, an antimicrobial agent with an extremely low water solubility, was included in the hydrophobic cavity of hydroxypropyl-β-cyclodextrins. Complex formation was evaluated by the Higuchi-Connors phase-solubility method and by UV difference spectrophotometry. The results obtained by both methods suggest that an inclusion complex of 1:1 stoichiometry is formed. The estimated association constant was close to 500 M -1, indicating a considerably high stability. As a result of complexation, triclosan solubility in aqueous ethanol (10% v/v) showed an almost 70-fold increase. Copyright © 2009, AIDIC Servizi S.r.l.

Experimental study of the inclusion of triclosan in hydroxy propyl-β-cyclodextrins / Lavecchia, Roberto; Zuorro, Antonio. - STAMPA. - 17:(2009), pp. 1083-1088. (Intervento presentato al convegno 9th International Conference on Chemical and Process Engineering, ICheaP-9 tenutosi a Rome nel 10 May 2009 through 13 May 2009) [10.3303/cet0917181].

Experimental study of the inclusion of triclosan in hydroxy propyl-β-cyclodextrins

LAVECCHIA, Roberto;ZUORRO, ANTONIO
2009

Abstract

Triclosan, an antimicrobial agent with an extremely low water solubility, was included in the hydrophobic cavity of hydroxypropyl-β-cyclodextrins. Complex formation was evaluated by the Higuchi-Connors phase-solubility method and by UV difference spectrophotometry. The results obtained by both methods suggest that an inclusion complex of 1:1 stoichiometry is formed. The estimated association constant was close to 500 M -1, indicating a considerably high stability. As a result of complexation, triclosan solubility in aqueous ethanol (10% v/v) showed an almost 70-fold increase. Copyright © 2009, AIDIC Servizi S.r.l.
2009
9th International Conference on Chemical and Process Engineering, ICheaP-9
04 Pubblicazione in atti di convegno::04c Atto di convegno in rivista
Experimental study of the inclusion of triclosan in hydroxy propyl-β-cyclodextrins / Lavecchia, Roberto; Zuorro, Antonio. - STAMPA. - 17:(2009), pp. 1083-1088. (Intervento presentato al convegno 9th International Conference on Chemical and Process Engineering, ICheaP-9 tenutosi a Rome nel 10 May 2009 through 13 May 2009) [10.3303/cet0917181].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/475229
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