The aim of this paper was to investigate the effect of glycerol on experimental endolymphatic hydrops in guinea-pigs. The right endolymphatic sac and duct were obliterated through an extradural posterior fossa approach. Some animals received a 3 g/kg dose of glycerol for a period of 7 days, whereas others received the same dose for 30 days. The activity of glycerol was studied by investigating the volumetric changes in the scala media determined with a computerized planimeter. Glycerol induced a significant reduction of the hydrops showing its effectiveness and suggesting a strial metabolic response.
The effect of glycerol on the guinea-pig hydropic ear / Magliulo, Giuseppe; Ungari, C; DELLA ROCCA, Carlo; Muscatello, M; Vingolo, G.. - In: CLINICAL OTOLARYNGOLOGY. - ISSN 0307-7772. - STAMPA. - 16(5):5(1991), pp. 483-487. [10.1111/j.1365-2273.1991.tb01045.x]
The effect of glycerol on the guinea-pig hydropic ear.
DELLA ROCCA, Carlo;
1991
Abstract
The aim of this paper was to investigate the effect of glycerol on experimental endolymphatic hydrops in guinea-pigs. The right endolymphatic sac and duct were obliterated through an extradural posterior fossa approach. Some animals received a 3 g/kg dose of glycerol for a period of 7 days, whereas others received the same dose for 30 days. The activity of glycerol was studied by investigating the volumetric changes in the scala media determined with a computerized planimeter. Glycerol induced a significant reduction of the hydrops showing its effectiveness and suggesting a strial metabolic response.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
