Class II MHC molecules are two-chain glycoproteins normally expressed only on the membrane of cells involved in the immune response. These molecules are restriction elements for helper T cells. Using indirect immunofluorescence on cryostat sections of biopsied salivary glands we have demonstrated epithelial expression of class II antigens in patients with Sjögren's syndrome. The HLA DR+ epithelial cells were seen in close proximity to lymphocyte infiltrates. The finding that class II molecules are also expressed in salivary glands without focal lymphocytic infiltrates suggests a "modulation" as opposed to "induction" of HLA DR antigens on epithelial cells in Sjögren's syndrome, the distinction being related to the enhancement of low levels of expressions vs. de novo synthesis.

Class II MHC antigen expression on epithelial cells of salivary glands from patients with Sjögren's syndrome / A., Franco; Valesini, Guido; Barnaba, Vincenzo; C., Silvagni; Tiberti, Antonio; F., Balsano. - In: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. - ISSN 0392-856X. - STAMPA. - 5:3(1987), pp. 199-203.

Class II MHC antigen expression on epithelial cells of salivary glands from patients with Sjögren's syndrome.

VALESINI, Guido;BARNABA, Vincenzo;TIBERTI, Antonio;
1987

Abstract

Class II MHC molecules are two-chain glycoproteins normally expressed only on the membrane of cells involved in the immune response. These molecules are restriction elements for helper T cells. Using indirect immunofluorescence on cryostat sections of biopsied salivary glands we have demonstrated epithelial expression of class II antigens in patients with Sjögren's syndrome. The HLA DR+ epithelial cells were seen in close proximity to lymphocyte infiltrates. The finding that class II molecules are also expressed in salivary glands without focal lymphocytic infiltrates suggests a "modulation" as opposed to "induction" of HLA DR antigens on epithelial cells in Sjögren's syndrome, the distinction being related to the enhancement of low levels of expressions vs. de novo synthesis.
1987
01 Pubblicazione su rivista::01a Articolo in rivista
Class II MHC antigen expression on epithelial cells of salivary glands from patients with Sjögren's syndrome / A., Franco; Valesini, Guido; Barnaba, Vincenzo; C., Silvagni; Tiberti, Antonio; F., Balsano. - In: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. - ISSN 0392-856X. - STAMPA. - 5:3(1987), pp. 199-203.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/473644
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