A definite association between the transcription of N-myc oncogene and proliferation-related genes, histone H3, c-myc and p53, was found in a set of 12 primary untreated neuroblastomas and a metastasis of one of these at relapse. Molecular analysis allowed us to discriminate between actually proliferating and non-proliferating tumors, and suggested a link between N-myc and proliferation. Flow cytometric analysis of DNA distribution was less reliable for assessing tumor proliferative activity. Our data also seem to indicate a down-regulation of c-myc by N-myc in human neuroblastoma.
TRANSCRIPTION OF N-MYC AND PROLIFERATION-RELATED GENES IS LINKED IN HUMAN NEUROBLASTOMA / G., Raschella; A., Negroni; C., Giubilei; A., Romeo; S., Ferrari; Castello, Manuel Adolfo; Dominici, Carlo. - In: CANCER LETTERS. - ISSN 0304-3835. - STAMPA. - 56:1(1991), pp. 45-51. [10.1016/0304-3835(91)90192-k]
TRANSCRIPTION OF N-MYC AND PROLIFERATION-RELATED GENES IS LINKED IN HUMAN NEUROBLASTOMA
CASTELLO, Manuel Adolfo;DOMINICI, Carlo
1991
Abstract
A definite association between the transcription of N-myc oncogene and proliferation-related genes, histone H3, c-myc and p53, was found in a set of 12 primary untreated neuroblastomas and a metastasis of one of these at relapse. Molecular analysis allowed us to discriminate between actually proliferating and non-proliferating tumors, and suggested a link between N-myc and proliferation. Flow cytometric analysis of DNA distribution was less reliable for assessing tumor proliferative activity. Our data also seem to indicate a down-regulation of c-myc by N-myc in human neuroblastoma.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
