The metabotropic glutamate (mGlu) receptor agonists, quisqualate and (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (ACPD), but not (RS)-3,5-dihydroxyphenylglycine or (2S,3S,45)-alpha-(carboxycyclopropyl)glycine, stimulated [H-3]inositolmonophosphate ([H-3]InsP) formation in primary cultures of rat hepatocytes. 1S,3R-ACPD-stimulated [H-3]InsP formation was inhibited by alpha-methyl-4-carboxyphenylglycine, indicating that cultured hepatocytes express functional mGlu receptors coupled to polyphosphoinositide hydrolysis. The identity of these receptors is not similar to that of any of the known mGlu receptor subtypes characterized in heterologous expression systems. (C) 1997 Elsevier Science B.V.
Metabotropic glutamate receptor agonists stimulate polyphosphoinositide hydrolysis in primary cultures of rat hepatocytes / Francesc, Sureda; Agata, Copani; Bruno, Valeria Maria Gloria; Thomas, Knopfel; Gainer, Meltzger; Nicoletti, Ferdinando. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - STAMPA. - 338:2(1997), pp. R1-R2. [10.1016/s0014-2999(97)81950-4]
Metabotropic glutamate receptor agonists stimulate polyphosphoinositide hydrolysis in primary cultures of rat hepatocytes
BRUNO, Valeria Maria Gloria;NICOLETTI, Ferdinando
1997
Abstract
The metabotropic glutamate (mGlu) receptor agonists, quisqualate and (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (ACPD), but not (RS)-3,5-dihydroxyphenylglycine or (2S,3S,45)-alpha-(carboxycyclopropyl)glycine, stimulated [H-3]inositolmonophosphate ([H-3]InsP) formation in primary cultures of rat hepatocytes. 1S,3R-ACPD-stimulated [H-3]InsP formation was inhibited by alpha-methyl-4-carboxyphenylglycine, indicating that cultured hepatocytes express functional mGlu receptors coupled to polyphosphoinositide hydrolysis. The identity of these receptors is not similar to that of any of the known mGlu receptor subtypes characterized in heterologous expression systems. (C) 1997 Elsevier Science B.V.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.