With the final aim to develop novel additional tools for the evaluation of exposure to malaria vectors we started an analysis of the human humoral response to recombinant salivary proteins of the major African vector Anopheles gambiae. We started focusing our efforts on gSG6 (gambiae Salivary Gland protein 6), a small protein specifically expressed in adult female glands where it plays some important role in blood feeding (Lanfrancotti A et al., 2002; Arcà B et al., 2005; Lombardo F et al., 2009). This protein seemed especially suitable because it is relatively abundant in the An. gambiae saliva, is restricted to anopheline species and earlier studies indicated its immunogenicity to humans (Orlandi-Pradines E et al., 2007; Poinsignon A et al., 2008).
The Anopheles gambiae gSG6 salivary protein: a serological marker of exposure to African malaria vectors / Rizzo, Cinzia; R., Ronca; G., Fiorentino; Verra, Federica; Mangano, Valentina; A., Poinsignon; B. S., Sirima; I., Nebie; F., Remoue; COLUZZI BARTOCCIONI, Caio Mario; Petrarca, Vincenzo; Modiano, David; Arca', Bruno. - STAMPA. - (2010), pp. 17-18. (Intervento presentato al convegno International Conference EDEN 2010 tenutosi a Montpellier (France) nel 10-12 Maggio 2010).
The Anopheles gambiae gSG6 salivary protein: a serological marker of exposure to African malaria vectors.
RIZZO, CINZIA;VERRA, FEDERICA;MANGANO, VALENTINA;COLUZZI BARTOCCIONI, Caio Mario;PETRARCA, Vincenzo;MODIANO, David;ARCA', Bruno
2010
Abstract
With the final aim to develop novel additional tools for the evaluation of exposure to malaria vectors we started an analysis of the human humoral response to recombinant salivary proteins of the major African vector Anopheles gambiae. We started focusing our efforts on gSG6 (gambiae Salivary Gland protein 6), a small protein specifically expressed in adult female glands where it plays some important role in blood feeding (Lanfrancotti A et al., 2002; Arcà B et al., 2005; Lombardo F et al., 2009). This protein seemed especially suitable because it is relatively abundant in the An. gambiae saliva, is restricted to anopheline species and earlier studies indicated its immunogenicity to humans (Orlandi-Pradines E et al., 2007; Poinsignon A et al., 2008).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
