Ten patients with difterent types of internal urinary diversion for bladder exstrophy were studied prospectively in order to assess metabolic abnormalities and morphological, histochemical and lectin binding changes in the colorectal mucosa. The histochemical and/or lectin binding changes which were found in the majority of patients were identical to those observed in premalignant and malignant conditions of the colon. In some cases they were detectable 3 years after the initial examination but were completely absent from the colorectal mucosa of normal subjects. Metabolic disturbances (metabolic acidosis, increased anion gap, hyperchloraemia)were observed in a substantial number of asymptomatic patients. These findings stress the need for regular endoscopic, histological and metabolic follow-up in these patients and for life-long treatment with bicarbonate or citrate.

Abnormalities of colonic mucin secretion and metabolic changes and internal urinary diversion for bladder exstrophy. A prospective study / A., Marcheggiano; D., Diosi; DE DOMINICIS, Carlo; Laurenti, Cesare; R., Caprilla. - In: BRITISH JOURNAL OF UROLOGY. - ISSN 0007-1331. - 67:(1991), pp. 477-482.

Abnormalities of colonic mucin secretion and metabolic changes and internal urinary diversion for bladder exstrophy. A prospective study

DE DOMINICIS, Carlo;LAURENTI, Cesare;
1991

Abstract

Ten patients with difterent types of internal urinary diversion for bladder exstrophy were studied prospectively in order to assess metabolic abnormalities and morphological, histochemical and lectin binding changes in the colorectal mucosa. The histochemical and/or lectin binding changes which were found in the majority of patients were identical to those observed in premalignant and malignant conditions of the colon. In some cases they were detectable 3 years after the initial examination but were completely absent from the colorectal mucosa of normal subjects. Metabolic disturbances (metabolic acidosis, increased anion gap, hyperchloraemia)were observed in a substantial number of asymptomatic patients. These findings stress the need for regular endoscopic, histological and metabolic follow-up in these patients and for life-long treatment with bicarbonate or citrate.
chloride, lectin; article, bladder exstrophy, blood level, cancer, child, clinical article, colon mucosa, female, human, male, metabolic acidosis, priority journal, urinary diversion; Adolescent, Adult, Bladder Exstrophy, Child, Child; Preschool, Colon, Comparative Study, Electrolytes, Female, Human, Intestinal Mucosa, Male, Mucins, Prospective Studies, Rectum, Ureter, Urinary Diversion
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Abnormalities of colonic mucin secretion and metabolic changes and internal urinary diversion for bladder exstrophy. A prospective study / A., Marcheggiano; D., Diosi; DE DOMINICIS, Carlo; Laurenti, Cesare; R., Caprilla. - In: BRITISH JOURNAL OF UROLOGY. - ISSN 0007-1331. - 67:(1991), pp. 477-482.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/472756
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