The glycerophosphorylcholine (GPC) levels in the brains of aged rats (≥24-mo-old) were increased relative to adult (6-mo-old) controls. In both adult and aged rats treatment with acetyl-L-carnitine (ALC) induced a significant increase in the phosphocreatine levels and decreases in the lactate and sugar phosphate levels. The GPC levels increased in adult controls and decreased in aged rats, depending on the ALC concns. Apparently, ALC modulates enzymes involved in the acylation-reacylation process in an age-dependent manner.

Effect of acetyl-L-carnitine on cerebral energy and phospholipid metabolism in adult and aged rats. Study by phosphorus-31 and proton NMR spectroscopy / Miccheli, Alfredo; T., Aureli; R., Ricciolini; Delfini, Maurizio; M. T., Ramacci; L., Angelucci; O., Ghirardi; F., Conti. - In: BULLETIN OF MAGNETIC RESONANCE. - ISSN 0163-559X. - STAMPA. - 11:3-4(1989), pp. 338-339.

Effect of acetyl-L-carnitine on cerebral energy and phospholipid metabolism in adult and aged rats. Study by phosphorus-31 and proton NMR spectroscopy

MICCHELI, Alfredo;DELFINI, Maurizio;
1989

Abstract

The glycerophosphorylcholine (GPC) levels in the brains of aged rats (≥24-mo-old) were increased relative to adult (6-mo-old) controls. In both adult and aged rats treatment with acetyl-L-carnitine (ALC) induced a significant increase in the phosphocreatine levels and decreases in the lactate and sugar phosphate levels. The GPC levels increased in adult controls and decreased in aged rats, depending on the ALC concns. Apparently, ALC modulates enzymes involved in the acylation-reacylation process in an age-dependent manner.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/472708
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