It has been suggested that thrombotic events occurring in patients with chronic obstructive pulmonary disease could be partially due to abnormalities in blood coagulation and fibrinolysis, as well as to changes in platelet function. In the present study in vitro platelet aggregation, in addition to clotting activity, has been studied in 20 patients with chronic obstructive pulmonary disease and different degrees of alteration of blood gas analysis. The results obtained suggest that the presence of a condition of platelet hypoaggregability characterizes patients with marked hypercapnia and/or hypoxemia, whereas the improvement of respiratory indexes is followed by a trend to normalization, or, more often, to an increase of platelet activity.
Chronic obstructive pulmonary disease. A possible correlation between platelet aggregation tests and respiratory indexes. ECOB Group / Gazzaniga, Pierpaolo; Basili, Stefania; Ferroni, Patrizia; Pulcinelli, FABIO MARIA; Pettirossi, Giovanni; R., La Mancusa; Alessandri, Cesare; Cordova, Corrado. - In: LA CLINICA TERAPEUTICA. - ISSN 0009-9074. - STAMPA. - 142:6(1993), pp. 507-516.
Chronic obstructive pulmonary disease. A possible correlation between platelet aggregation tests and respiratory indexes. ECOB Group.
GAZZANIGA, Pierpaolo;BASILI, Stefania;FERRONI, Patrizia;PULCINELLI, FABIO MARIA;PETTIROSSI, Giovanni;ALESSANDRI, Cesare;CORDOVA, Corrado
1993
Abstract
It has been suggested that thrombotic events occurring in patients with chronic obstructive pulmonary disease could be partially due to abnormalities in blood coagulation and fibrinolysis, as well as to changes in platelet function. In the present study in vitro platelet aggregation, in addition to clotting activity, has been studied in 20 patients with chronic obstructive pulmonary disease and different degrees of alteration of blood gas analysis. The results obtained suggest that the presence of a condition of platelet hypoaggregability characterizes patients with marked hypercapnia and/or hypoxemia, whereas the improvement of respiratory indexes is followed by a trend to normalization, or, more often, to an increase of platelet activity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
