The etiology and pathogenesis of Peyronie's disease (IPP) are still unknown, although various theories have been proposed. In IPP the pathogenetic mechanism seems to consist of an initial pathogenetic noxa causing the following steps: vasculitis of the tunica albuginea, plasmatic effusion, incomplete fibrinolisis that determines an activation of fibroblasts resulting in a subfascial keloid. In order to better define the modifications determined in the tunica albuginea of pathological corpus cavernosum, we have analyzed the ultrastructural morphology and then evaluated the expression and distribution of collagen and platelet derived growth factor (PDGF).
The etiopathogenesis of IPP: Old and new theories / Gentile, Vincenzo; P., Di Palma; G., Gentile; R., Lucera. - In: ACTA UROLOGICA ITALICA. - ISSN 0394-2511. - STAMPA. - 12:3(1998), pp. 165-167.
The etiopathogenesis of IPP: Old and new theories
GENTILE, Vincenzo;
1998
Abstract
The etiology and pathogenesis of Peyronie's disease (IPP) are still unknown, although various theories have been proposed. In IPP the pathogenetic mechanism seems to consist of an initial pathogenetic noxa causing the following steps: vasculitis of the tunica albuginea, plasmatic effusion, incomplete fibrinolisis that determines an activation of fibroblasts resulting in a subfascial keloid. In order to better define the modifications determined in the tunica albuginea of pathological corpus cavernosum, we have analyzed the ultrastructural morphology and then evaluated the expression and distribution of collagen and platelet derived growth factor (PDGF).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
