Berger's disease, or IgA mesangial nephropathy, is a frequent form of focal and/or segmental proliferative glomerulonephritis that occasionally may present as nephrotic syndrome. The authors reports a clinical case of a young woman come to their observation with a severe clinical picture characterized by asthenia, anasarca, serious no selective proteinuria, microscopic hematuria, blood hypotension from mesangial proliferative glomerulonephritis IgA. Because of the null response to traditional therapy the patient was submitted to plasmapheresis "cascade model", or double filtration, a certainly experimental treatment for this disease, and a remission of the nephrotic syndrome was obtained as confirmed by follow-up at three, six months and one year. Since at present times the therapy is supportive only and no therapeutic maneuvers have been found to be consistently effective in the Berger's disease, plasma exchange plus immunodepressive therapy seems to be useful particularly in the rare patients with rapidly progressive glomerulonephritis. Further and more extensive studies and a fair follow-up are necessary to prove our results.
[The usefulness of plasmapheresis in a case of nephrotic syndrome in Berger's disease] / Pergolini, Mario Sergio; Coppotelli, Luigi; M., Paradiso; Mammarella, Antonio; P., Boccia; M., Leonardo; Basili, Stefania; Pettirossi, Giovanni; Paoletti, Vincenzo; Cordova, Corrado. - In: LA CLINICA TERAPEUTICA. - ISSN 0009-9074. - STAMPA. - 147:11(1996), pp. 543-547.
[The usefulness of plasmapheresis in a case of nephrotic syndrome in Berger's disease].
PERGOLINI, Mario Sergio;COPPOTELLI, Luigi;MAMMARELLA, Antonio;BASILI, Stefania;PETTIROSSI, Giovanni;PAOLETTI, Vincenzo;CORDOVA, Corrado
1996
Abstract
Berger's disease, or IgA mesangial nephropathy, is a frequent form of focal and/or segmental proliferative glomerulonephritis that occasionally may present as nephrotic syndrome. The authors reports a clinical case of a young woman come to their observation with a severe clinical picture characterized by asthenia, anasarca, serious no selective proteinuria, microscopic hematuria, blood hypotension from mesangial proliferative glomerulonephritis IgA. Because of the null response to traditional therapy the patient was submitted to plasmapheresis "cascade model", or double filtration, a certainly experimental treatment for this disease, and a remission of the nephrotic syndrome was obtained as confirmed by follow-up at three, six months and one year. Since at present times the therapy is supportive only and no therapeutic maneuvers have been found to be consistently effective in the Berger's disease, plasma exchange plus immunodepressive therapy seems to be useful particularly in the rare patients with rapidly progressive glomerulonephritis. Further and more extensive studies and a fair follow-up are necessary to prove our results.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.