A purified extract of Orobanche hederae, composed of two phenylpropanoid glycosides, verbascoside and orobanchoside (55:45), was investigated for its pharmacological profile. The extract did not exert significant changes on the nociceptive threshold in the hot plate test; no effect was registered on guinea-pig ileum. On the other hand, the phenylpropanoid glycoside mixture significantly prolonged sleep induced by pentobarbital and affected locomotor activity in mice; it also produced a slowing of the electroencephalographic trace and induced, when injected in the lateral cerebral ventricle, epileptiform activity in male rabbits. These effects may suggest neuroleptic-like properties.

PHARMACOLOGICAL EFFECTS OF PHENYLPROPANOID GLYCOSIDES FROM OROBANCHE-HEDERAE / Nicoletti, Marcello; S., Pieretti; A., Di Giannuario; A., Capasso. - In: PHYTOTHERAPY RESEARCH. - ISSN 0951-418X. - STAMPA. - 6:2(1992), pp. 89-93. [10.1002/ptr.2650060208]

PHARMACOLOGICAL EFFECTS OF PHENYLPROPANOID GLYCOSIDES FROM OROBANCHE-HEDERAE

NICOLETTI, Marcello;
1992

Abstract

A purified extract of Orobanche hederae, composed of two phenylpropanoid glycosides, verbascoside and orobanchoside (55:45), was investigated for its pharmacological profile. The extract did not exert significant changes on the nociceptive threshold in the hot plate test; no effect was registered on guinea-pig ileum. On the other hand, the phenylpropanoid glycoside mixture significantly prolonged sleep induced by pentobarbital and affected locomotor activity in mice; it also produced a slowing of the electroencephalographic trace and induced, when injected in the lateral cerebral ventricle, epileptiform activity in male rabbits. These effects may suggest neuroleptic-like properties.
1992
phenylpropanoid glycosides; central nervous system; orobanche-hederae; pharmacology
01 Pubblicazione su rivista::01a Articolo in rivista
PHARMACOLOGICAL EFFECTS OF PHENYLPROPANOID GLYCOSIDES FROM OROBANCHE-HEDERAE / Nicoletti, Marcello; S., Pieretti; A., Di Giannuario; A., Capasso. - In: PHYTOTHERAPY RESEARCH. - ISSN 0951-418X. - STAMPA. - 6:2(1992), pp. 89-93. [10.1002/ptr.2650060208]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/470495
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