The role of the pituitary-adrenal axis in the inhibition of gastric emptying caused by intracerebroventricular (i.c.v.) administration of dermorphin was examined. Dermorphin given i.c.v. (1, 10, 100 ng per rat) slowed emptying in a dose-related manner. Hypophysectomy or sub-diaphragmatic bivagotomy reduced, and adrenalectomy prevented the inhibition of gastric emptying associated with dermorphin. Dermorphin inhibition of gastric emptying is thus specially dependent upon intact adrenals.
Pituitary-adrenal mediation of dermorphin-induced inhibition of gastric emptying in rats / Broccardo, Maria. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - STAMPA. - 142:(1987), pp. 151-154. [10.1016/0014-2999(87)90666-2]
Pituitary-adrenal mediation of dermorphin-induced inhibition of gastric emptying in rats.
BROCCARDO, Maria
1987
Abstract
The role of the pituitary-adrenal axis in the inhibition of gastric emptying caused by intracerebroventricular (i.c.v.) administration of dermorphin was examined. Dermorphin given i.c.v. (1, 10, 100 ng per rat) slowed emptying in a dose-related manner. Hypophysectomy or sub-diaphragmatic bivagotomy reduced, and adrenalectomy prevented the inhibition of gastric emptying associated with dermorphin. Dermorphin inhibition of gastric emptying is thus specially dependent upon intact adrenals.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
