The synthesis and antifungal activities of the cis- and trans-1-acetyl-4-[4-[[2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethy l)- 1,3-dioxolan-4-yl]-methoxy]phenyl)piperazines 3 and 4 are reported. Stereochemical assignments to diastereomeric pairs of cis/trans isomers were made on the basis of 1H- and 13C-NMR data. Among test derivatives the best activity was shown by the benzoyl esters of the cis- and trans-[2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3-di oxolan-4- yl]methanols 9 and 10.

Antibacterial and antifungal agents. XV. Synthesis and antifungal activity of structural analogues of bifonazole and ketoconazole / Stefancich, Giorgio; Artico, Marco; Ortar, Giorgio; Silvestri, Romano; Simonetti, Giovanna; Germana, Apuzzo; Artico, Marino. - In: ARCHIV DER PHARMAZIE. - ISSN 0365-6233. - 325:11(1992), pp. 687-694. [10.1002/ardp.19923251102]

Antibacterial and antifungal agents. XV. Synthesis and antifungal activity of structural analogues of bifonazole and ketoconazole.

ARTICO, Marco;ORTAR, Giorgio;SILVESTRI, Romano;SIMONETTI, Giovanna;ARTICO, Marino
1992

Abstract

The synthesis and antifungal activities of the cis- and trans-1-acetyl-4-[4-[[2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethy l)- 1,3-dioxolan-4-yl]-methoxy]phenyl)piperazines 3 and 4 are reported. Stereochemical assignments to diastereomeric pairs of cis/trans isomers were made on the basis of 1H- and 13C-NMR data. Among test derivatives the best activity was shown by the benzoyl esters of the cis- and trans-[2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3-di oxolan-4- yl]methanols 9 and 10.
1992
01 Pubblicazione su rivista::01a Articolo in rivista
Antibacterial and antifungal agents. XV. Synthesis and antifungal activity of structural analogues of bifonazole and ketoconazole / Stefancich, Giorgio; Artico, Marco; Ortar, Giorgio; Silvestri, Romano; Simonetti, Giovanna; Germana, Apuzzo; Artico, Marino. - In: ARCHIV DER PHARMAZIE. - ISSN 0365-6233. - 325:11(1992), pp. 687-694. [10.1002/ardp.19923251102]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/470114
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