Racemic 6-[4-(3'-hydroxy-1'-octenyl)-3-pyridyloxy]hexanoic and 6-[4-(3'-hydroxyoctyl)-3-pyridyloxy] exanoic acids have been synthesized and their activity as inhibitors of the biosynthesis of thromboxane A2 in human serum has been studied, in comparison with isomers having the eight-carbon chain in the 2 position. Very high, selective activity was found for the new 4-substituted 3-pyridinol ethers, whereas the 2-substituted compounds showed no action.
INHIBITION OF THROMBOXANE BIOSYNTHESIS BY 3-PYRIDINOL CARBOXYPENTYL ETHERS SUBSTITUTED WITH A HYDROXYLATED OCTYL CHAIN / S., Conti; Desideri, Nicoletta; S., Passaghe; M. N., Castagnoli; C., Cerletti; Stein, Maria Luisa. - In: JOURNAL OF PHARMACY AND PHARMACOLOGY. - ISSN 0022-3573. - 40:2(1988), pp. 144-146. [10.1111/j.2042-7158.1988.tb05203.x]
INHIBITION OF THROMBOXANE BIOSYNTHESIS BY 3-PYRIDINOL CARBOXYPENTYL ETHERS SUBSTITUTED WITH A HYDROXYLATED OCTYL CHAIN
DESIDERI, Nicoletta;STEIN, Maria Luisa
1988
Abstract
Racemic 6-[4-(3'-hydroxy-1'-octenyl)-3-pyridyloxy]hexanoic and 6-[4-(3'-hydroxyoctyl)-3-pyridyloxy] exanoic acids have been synthesized and their activity as inhibitors of the biosynthesis of thromboxane A2 in human serum has been studied, in comparison with isomers having the eight-carbon chain in the 2 position. Very high, selective activity was found for the new 4-substituted 3-pyridinol ethers, whereas the 2-substituted compounds showed no action.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
