Group-II metabotropic glutamate (mGlu) receptors (mGlu2/3 receptors) were highly expressed in various regions (telencephalon, optic tectum, and cerebellum, but not vagal lobe) of the goldfish brain. In the,goldfish telencephalon, expression of mGlu2/3 receptors was even higher than in the rat cerebral cortex. In contrast, mGlu5 receptors showed low levels of expression in all goldfish brain regions, whereas mGlu1a receptors were only expressed in the,goldfish cerebellum. Pharmacological activation of group-II mGlu receptors with the selective agonists, 2R,4R-4-aminopyrrolidine-2,4-dicarboxylic acid and (2, 3,2'R,3'R)-2-(2,3-dicarbaxycyclopropyl) glycine, reduced the evoked release of glutamate from goldfish brain synaptosomes, whereas agonists of group-I and -III mGlu receptors (3,5-dihydroxy-phenylglycine and L-2-amino-4-phosphonobutanoate) were inactive. The predominance of group-II over group-I mGlu receptors in the goldfish brain may provide a natural defense against excitotoxic neuronal death and contribute to the unusually high resistance of goldfishes against hypoxic brain damage. (C) 1999 Published by Elsevier Science B.V. All rights reserved.
Predominant expression of group-II metabotropic glutamate receptors in the goldfish brain / A., Poli; R., Lucchi; M., Storto; P. D., Paolis; S., Notari; Nicoletti, Ferdinando; G., Casabona. - In: BRAIN RESEARCH. - ISSN 0006-8993. - 834:1-2(1999), pp. 142-145. [10.1016/s0006-8993(99)01518-8]
Predominant expression of group-II metabotropic glutamate receptors in the goldfish brain
NICOLETTI, Ferdinando;
1999
Abstract
Group-II metabotropic glutamate (mGlu) receptors (mGlu2/3 receptors) were highly expressed in various regions (telencephalon, optic tectum, and cerebellum, but not vagal lobe) of the goldfish brain. In the,goldfish telencephalon, expression of mGlu2/3 receptors was even higher than in the rat cerebral cortex. In contrast, mGlu5 receptors showed low levels of expression in all goldfish brain regions, whereas mGlu1a receptors were only expressed in the,goldfish cerebellum. Pharmacological activation of group-II mGlu receptors with the selective agonists, 2R,4R-4-aminopyrrolidine-2,4-dicarboxylic acid and (2, 3,2'R,3'R)-2-(2,3-dicarbaxycyclopropyl) glycine, reduced the evoked release of glutamate from goldfish brain synaptosomes, whereas agonists of group-I and -III mGlu receptors (3,5-dihydroxy-phenylglycine and L-2-amino-4-phosphonobutanoate) were inactive. The predominance of group-II over group-I mGlu receptors in the goldfish brain may provide a natural defense against excitotoxic neuronal death and contribute to the unusually high resistance of goldfishes against hypoxic brain damage. (C) 1999 Published by Elsevier Science B.V. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
