Use of herbal plant remedies to treat infectious diseases is a common practice in many countries in traditional and alternative medicine. However to date there are only few antimicrobial agents derived from botanics. Based on microbiological screening tests of crude plant extracts we identified four compounds derived from Krameria, Aesculus hippocastanum and Chelidonium majus that showed a potentially interesting antimicrobial activity. In this work we present an in depth characterization of the inhibition activity of these pure compounds on the formation of biofilm of Staphylococcus aureus as well as of Staphylococcus epidermidis strains. We show that two of these compounds possess interesting potential to become active principles of new drugs. © 2011 Elsevier Ltd. All rights reserved.
Bacterial biofilm formation inhibitory activity revealed for plant derived natural compounds / Artini, Marco; Papa, Rosanna; G., Barbato; Scoarughi, Gian Luca; Cellini, Andrea; P., Morazzoni; E., Bombardelli; Selan, Laura. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 1464-3391. - STAMPA. - 20:2(2012), pp. 920-926. [10.1016/j.bmc.2011.11.052]
Bacterial biofilm formation inhibitory activity revealed for plant derived natural compounds
ARTINI, Marco;PAPA, Rosanna;SCOARUGHI, Gian Luca;CELLINI, ANDREA;SELAN, Laura
2012
Abstract
Use of herbal plant remedies to treat infectious diseases is a common practice in many countries in traditional and alternative medicine. However to date there are only few antimicrobial agents derived from botanics. Based on microbiological screening tests of crude plant extracts we identified four compounds derived from Krameria, Aesculus hippocastanum and Chelidonium majus that showed a potentially interesting antimicrobial activity. In this work we present an in depth characterization of the inhibition activity of these pure compounds on the formation of biofilm of Staphylococcus aureus as well as of Staphylococcus epidermidis strains. We show that two of these compounds possess interesting potential to become active principles of new drugs. © 2011 Elsevier Ltd. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
