In the search of a convenient synthesis for isocordoin (1), a potential anticancer natural product, 2 ' ,4 ' -dihydroxychalcone was inoculated in cell suspension cultures of Morus nigro, which were expected to contain an active prenyltransferase. After 24 hours the target compound was easily isolated from the metabolite extract. Optimization of the biotransformation resulted in a 85% yield of the prenyl derivative.
Synthesis and biosynthesis of isocordoin / Alberto, Vitali; Franco, Ferrari; G. D., Monache; Ezio, Bombardelli; Botta, Bruno. - In: PLANTA MEDICA. - ISSN 0032-0943. - 67:5(2001), pp. 475-477. [10.1055/s-2001-15814]
Synthesis and biosynthesis of isocordoin
BOTTA, Bruno
2001
Abstract
In the search of a convenient synthesis for isocordoin (1), a potential anticancer natural product, 2 ' ,4 ' -dihydroxychalcone was inoculated in cell suspension cultures of Morus nigro, which were expected to contain an active prenyltransferase. After 24 hours the target compound was easily isolated from the metabolite extract. Optimization of the biotransformation resulted in a 85% yield of the prenyl derivative.File allegati a questo prodotto
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