The major concern for the use of adenoviral vectors for gene therapy is the viral-induced immune response that has been shown to be responsible for short-term transgene expression and inefficient viral readministration. In vivo studies and clinical trials with recombinant adenovirus have suggested a role for interleukin 6 (IL-6) in the inflammatory reaction that follows Ad-infection. IL-6 plays an important role in the acute-phase innate response, in the differentiation of B-cells and in the activation of the Th2 cell subsets.
The role of IL6 in the inflammatory and humoral response to adenoviral vectors / K., Benihoud; Salone, Barbara; S., Esselin; P., Opolon; V., Poli; DI GIOVINE, Monica; M., Perricaudet; Saggio, Isabella. - In: THE JOURNAL OF GENE MEDICINE. - ISSN 1099-498X. - STAMPA. - 2:3(2000), pp. 194-203. [10.1002/(SICI)1521-2254(200005/06)2:3<194::AID-JGM102>3.0.CO;2-5]
The role of IL6 in the inflammatory and humoral response to adenoviral vectors
SALONE, Barbara;DI GIOVINE, Monica;SAGGIO, Isabella
2000
Abstract
The major concern for the use of adenoviral vectors for gene therapy is the viral-induced immune response that has been shown to be responsible for short-term transgene expression and inefficient viral readministration. In vivo studies and clinical trials with recombinant adenovirus have suggested a role for interleukin 6 (IL-6) in the inflammatory reaction that follows Ad-infection. IL-6 plays an important role in the acute-phase innate response, in the differentiation of B-cells and in the activation of the Th2 cell subsets.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
