Isoliquiritigenin, glabridin, licoarylcoumarin and licoricidin were identified as strong inhibitors of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase in waste materials which were obtained during the industrial extraction of glycyrrhizin from licorice roots. The structure-activity relationships of 12 flavonoids from licorice roots and 34 4-arylcoumarins were studied. In 4-arylcoumarins, 5,7-dihydroxy derivatives were generally highly inhibitory towards cAMP phosphodiesterase.
INHIBITORS OF CAMP PHOSPHODIESTERASE IN MEDICINAL-PLANTS .17. INHIBITION OF ADENOSINE 3',5'-CYCLIC-MONOPHOSPHATE PHOSPHODIESTERASE BY FLAVONOIDS FROM LICORICE ROOTS AND 4-ARYLCOUMARINS / A., K., T., N., T., K., T., O., G., D., Botta, B., M., B., T., S.. - In: CHEMICAL & PHARMACEUTICAL BULLETIN. - ISSN 0009-2363. - 39:(1991), pp. 930-933.
INHIBITORS OF CAMP PHOSPHODIESTERASE IN MEDICINAL-PLANTS .17. INHIBITION OF ADENOSINE 3',5'-CYCLIC-MONOPHOSPHATE PHOSPHODIESTERASE BY FLAVONOIDS FROM LICORICE ROOTS AND 4-ARYLCOUMARINS
BOTTA, Bruno;
1991
Abstract
Isoliquiritigenin, glabridin, licoarylcoumarin and licoricidin were identified as strong inhibitors of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase in waste materials which were obtained during the industrial extraction of glycyrrhizin from licorice roots. The structure-activity relationships of 12 flavonoids from licorice roots and 34 4-arylcoumarins were studied. In 4-arylcoumarins, 5,7-dihydroxy derivatives were generally highly inhibitory towards cAMP phosphodiesterase.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
