Some analogues of the hypotensive agent caracasanamide have been synthesized and tested in vivo for cardiovascular effects. Derivative 2c emerged as the most interesting compound in the series. Structure-activity relationship is also discussed.
Synthesis and preliminary pharmacological evaluation of analogues of caracasanamide, a hypotensive natural product / Federico, Corelli; Donata, Dei; G., Dellemonache; Botta, Bruno; C., Deluca; Marco, Carmignani; A. R., Volpe; Maurizio, Botta. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 6:6(1996), pp. 653-658. [10.1016/0960-894x(96)00079-0]
Synthesis and preliminary pharmacological evaluation of analogues of caracasanamide, a hypotensive natural product
BOTTA, Bruno;
1996
Abstract
Some analogues of the hypotensive agent caracasanamide have been synthesized and tested in vivo for cardiovascular effects. Derivative 2c emerged as the most interesting compound in the series. Structure-activity relationship is also discussed.File allegati a questo prodotto
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