Aldehydes RCHO [R = C6H4OH-4, C6H3(OH)2-3,4, C6H3(OMe)OH-3,4, C6H2(OMe)2OH-3,5,4] were 20-90% deuterated by acid catalyzed exchange in 6N DCl-D2O at 80° for 12-72 h. PhCHO was 30% deuterated using 36 N D2SO4-D2O at 80° for 114 h. RCHO (same R's) and PhCHO were similarly tritiated, using HTO and acid. The tritiated aldehydes underwent condensation with H2C(CO2H) to give tritiated cinnamic acids R1CH:CHCO2H (R1 = tritiated Ph, R) with 35-87% chem. yield based on tritiated aldehyde, and specific activities of 5.6-118 Ci/mol.
Preparation of substituted cinnamic acids labeled with deuterium and tritium at the ring positions / Angelini, Giancarlo; Speranza, Maurizio; M., Felici; M., Luna. - In: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY. - ISSN 0236-5731. - STAMPA. - 87:(1984), pp. 283-289.
Preparation of substituted cinnamic acids labeled with deuterium and tritium at the ring positions
ANGELINI, Giancarlo;SPERANZA, Maurizio;
1984
Abstract
Aldehydes RCHO [R = C6H4OH-4, C6H3(OH)2-3,4, C6H3(OMe)OH-3,4, C6H2(OMe)2OH-3,5,4] were 20-90% deuterated by acid catalyzed exchange in 6N DCl-D2O at 80° for 12-72 h. PhCHO was 30% deuterated using 36 N D2SO4-D2O at 80° for 114 h. RCHO (same R's) and PhCHO were similarly tritiated, using HTO and acid. The tritiated aldehydes underwent condensation with H2C(CO2H) to give tritiated cinnamic acids R1CH:CHCO2H (R1 = tritiated Ph, R) with 35-87% chem. yield based on tritiated aldehyde, and specific activities of 5.6-118 Ci/mol.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
