Spongiform encephalopathies are characterized above all by spongiosis. This neuropathological characteristic is morphologically mimed by in vivo inhibition of cerebral brain Na,K-ATPase by means of subdural administration of ouabain. In this paper we underline the possibility that the ‘spongiotic state’ in other diseases might also be caused by the inhibition of this enzyme, thus hypothesizing that it is the enzyme itself that is targeted by the infective agent. The infective agent could, we believe, be shown to be linked to the enzyme if it were separated from the infected brain.
SPONGY STATE (STATUS SPONGIOSUS) AND INHIBITION OF NA,K-ATPASE - A PATHOGENETIC THEORY / Calandriello, L; Curini, Roberta; Pennisi, Em; Palladini, G.. - In: MEDICAL HYPOTHESES. - ISSN 0306-9877. - STAMPA. - 44:3(1995), pp. 173-178. [10.1016/0306-9877(95)90132-9]
SPONGY STATE (STATUS SPONGIOSUS) AND INHIBITION OF NA,K-ATPASE - A PATHOGENETIC THEORY
CURINI, Roberta;
1995
Abstract
Spongiform encephalopathies are characterized above all by spongiosis. This neuropathological characteristic is morphologically mimed by in vivo inhibition of cerebral brain Na,K-ATPase by means of subdural administration of ouabain. In this paper we underline the possibility that the ‘spongiotic state’ in other diseases might also be caused by the inhibition of this enzyme, thus hypothesizing that it is the enzyme itself that is targeted by the infective agent. The infective agent could, we believe, be shown to be linked to the enzyme if it were separated from the infected brain.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
