Sauvagine, a linear peptide of 40 amino acids, produced hypotension when administered intravenously to anesthetized dogs. Diastolic pressure was always more affected than systolic pressure. Aortic blood flow and venous return both increased to the same extent. The mechanism of the hypotensive response was mainly, if not exclusively, due to dilatation of the superior and inferior mesenteric arteries. Intravenous infusion of sauvagine in doses ranging from 3 to 10 ng . kg-1 . min-1 produced a dose-related increase of mesenteric blood flow up to 400% control values. Mucosal-submucosal blood flow of ileum and colon was increased, while blood flow in muscle was unaffected or slight decreased. The mesenteric vasodilator response was not prevented by adrenergic or muscarinic receptor blockade. The hypotensive response was more marked and sustained in dibenamine-propranolol treated dogs.
Action of sauvagine on the mesenteric vascular bed of the dog. / Melchiorri, Pietro; Negri, Lucia. - In: REGULATORY PEPTIDES. - ISSN 0167-0115. - STAMPA. - 2:1(1981), pp. 1-13.
Scheda prodotto non validato
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo
|Titolo:||Action of sauvagine on the mesenteric vascular bed of the dog.|
|Data di pubblicazione:||1981|
|Citazione:||Action of sauvagine on the mesenteric vascular bed of the dog. / Melchiorri, Pietro; Negri, Lucia. - In: REGULATORY PEPTIDES. - ISSN 0167-0115. - STAMPA. - 2:1(1981), pp. 1-13.|
|Appartiene alla tipologia:||01a Articolo in rivista|