Repeated (once a day for 8 days) but not single administration of estradiol benzoate (10 μg/kg, s.c.) induced a sevenfold increase in anterior pituitary γ-aminobutyric acid (GABA) concentration in male rats. GABA concentration also increased in the median eminence whereas no changes or decreases were observed in other brain regions including hypothalamic arcuate nucleus, lateral septum, hippocampus, caudate nucleus, and substantia nigra. Eight-day estradiol benzoate injection also enhanced the V(max) of median eminence glutamate decarboxylase activity without affecting the K(m) of the enzyme for glutamic acid. Taken together, these results suggest that repeated administration of estradiol benzoate increases the activity of the tubero-infundibular GABAergic system in male rats.

Effects of repeated administration of estradiol benzoate on tubero-infundibular GABAergic activity in male rats / Nicoletti, Ferdinando; Lindsey, Grandison; James L., Meek. - In: JOURNAL OF NEUROCHEMISTRY. - ISSN 0022-3042. - 44:4(1985), pp. 1217-1220. [10.1111/j.1471-4159.1985.tb08746.x]

Effects of repeated administration of estradiol benzoate on tubero-infundibular GABAergic activity in male rats

NICOLETTI, Ferdinando;
1985

Abstract

Repeated (once a day for 8 days) but not single administration of estradiol benzoate (10 μg/kg, s.c.) induced a sevenfold increase in anterior pituitary γ-aminobutyric acid (GABA) concentration in male rats. GABA concentration also increased in the median eminence whereas no changes or decreases were observed in other brain regions including hypothalamic arcuate nucleus, lateral septum, hippocampus, caudate nucleus, and substantia nigra. Eight-day estradiol benzoate injection also enhanced the V(max) of median eminence glutamate decarboxylase activity without affecting the K(m) of the enzyme for glutamic acid. Taken together, these results suggest that repeated administration of estradiol benzoate increases the activity of the tubero-infundibular GABAergic system in male rats.
1985
01 Pubblicazione su rivista::01a Articolo in rivista
Effects of repeated administration of estradiol benzoate on tubero-infundibular GABAergic activity in male rats / Nicoletti, Ferdinando; Lindsey, Grandison; James L., Meek. - In: JOURNAL OF NEUROCHEMISTRY. - ISSN 0022-3042. - 44:4(1985), pp. 1217-1220. [10.1111/j.1471-4159.1985.tb08746.x]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/466034
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