(2S,1'R,2'R,3'R)-2-(2,3-Dicarboxycyclopropyl)glycine (DCG-IV), a potent agonist of subtypes 2 and 3 of metabotropic glutamate receptors (mGluR2 or 3), protected cultured cortical neurons against excitotoxicity induced either by a brief exposure to N-methyl-D-aspartate (NMDA) or a prolonged exposure to kainate. As a neuroprotective agent, DCG-IV was much more potent than the mixed agonists 1S,3R-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) or (2S,1'S,2'S)-2-(carboxycyclopropyl)glycine (L-CCG-I), suggesting a neuroprotective role for mGluR2 or 3 against excitotoxic neuronal death.
Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death / Bruno, Valeria Maria Gloria; A., Copani; Battaglia, Giuseppe; R., Raffaele; H., Shinozaki; Nicoletti, Ferdinando. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - 256:(1994), pp. 109-112. [10.1016/0014-2999(94)90624-6]
Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death.
BRUNO, Valeria Maria Gloria;BATTAGLIA, Giuseppe;NICOLETTI, Ferdinando
1994
Abstract
(2S,1'R,2'R,3'R)-2-(2,3-Dicarboxycyclopropyl)glycine (DCG-IV), a potent agonist of subtypes 2 and 3 of metabotropic glutamate receptors (mGluR2 or 3), protected cultured cortical neurons against excitotoxicity induced either by a brief exposure to N-methyl-D-aspartate (NMDA) or a prolonged exposure to kainate. As a neuroprotective agent, DCG-IV was much more potent than the mixed agonists 1S,3R-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) or (2S,1'S,2'S)-2-(carboxycyclopropyl)glycine (L-CCG-I), suggesting a neuroprotective role for mGluR2 or 3 against excitotoxic neuronal death.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
