The novel free radical scavenger and electron-trapping agent, idebenone, protects cultured cortical neurons against necrotic degeneration induced by either a brief exposure to N-methyl-D-aspartate (NMDA) or a prolonged exposure to kainate. As opposed to the NMDA receptor antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]- cyclohepten-5,10-imine hydrogen maleate (MK801), idebenone rescued cortical neurons even when applied 30 min after the NMDA pulse, suggesting that the drug interferes with the chain of toxic reactions triggered by an excessive stimulation of excitatory amino acid receptors.
Protective action of idebenone against excitotoxic degeneration in cultured cortical neurons / Bruno, Valeria Maria Gloria; Battaglia, Giuseppe; A., Copani; M. A., Sortino; P. L., Canonico; Nicoletti, Ferdinando. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - 178:(1994), pp. 193-196. [10.1016/0304-3940(94)90757-9]
Protective action of idebenone against excitotoxic degeneration in cultured cortical neurons.
BRUNO, Valeria Maria Gloria;BATTAGLIA, Giuseppe;NICOLETTI, Ferdinando
1994
Abstract
The novel free radical scavenger and electron-trapping agent, idebenone, protects cultured cortical neurons against necrotic degeneration induced by either a brief exposure to N-methyl-D-aspartate (NMDA) or a prolonged exposure to kainate. As opposed to the NMDA receptor antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]- cyclohepten-5,10-imine hydrogen maleate (MK801), idebenone rescued cortical neurons even when applied 30 min after the NMDA pulse, suggesting that the drug interferes with the chain of toxic reactions triggered by an excessive stimulation of excitatory amino acid receptors.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
