We have investigated in the present study the effect of Mg(2+)-valproate on necrotic degeneration induced by an excitotoxic insult in primary culture of cerebellar neurons, that is an homogeneous population of glutamatergic neurons. Mg(2+)-valproate protected cultures against glutamate-induced neurotoxicity, acting as an indirect N-methyl-D-aspartate (NMDA) receptor antagonist, thus reducing free radical formation and affecting the biochemical parameters (i.e. 45Ca(2+)-influx, cyclic GMP formation, inositol phospholipid hydrolysis and protein kinase C translocation) that undergo modifications following NMDA receptor activation in cerebellar granule cells.

Antidegenerative effects of Mg(2+)-valproate in cultured cerebellar neurons / Bruno, Valeria Maria Gloria; M. A., Sortino; U., Scapagnini; Nicoletti, Ferdinando; P. L., Canonico. - In: FUNCTIONAL NEUROLOGY. - ISSN 0393-5264. - 10:(1995), pp. 121-130.

Antidegenerative effects of Mg(2+)-valproate in cultured cerebellar neurons.

BRUNO, Valeria Maria Gloria;NICOLETTI, Ferdinando;
1995

Abstract

We have investigated in the present study the effect of Mg(2+)-valproate on necrotic degeneration induced by an excitotoxic insult in primary culture of cerebellar neurons, that is an homogeneous population of glutamatergic neurons. Mg(2+)-valproate protected cultures against glutamate-induced neurotoxicity, acting as an indirect N-methyl-D-aspartate (NMDA) receptor antagonist, thus reducing free radical formation and affecting the biochemical parameters (i.e. 45Ca(2+)-influx, cyclic GMP formation, inositol phospholipid hydrolysis and protein kinase C translocation) that undergo modifications following NMDA receptor activation in cerebellar granule cells.
1995
Animals, Calcium; metabolism, Cells; Cultured, Cerebellum; chemistry/drug effects, Cyclic GMP; analysis/biosynthesis, Free Radicals; analysis, Glutamic Acid; metabolism/pharmacology/toxicity, Magnesium; analysis/pharmacology, Nerve Degeneration; drug effects, Neurons; chemistry/drug effects, Neurotoxins; biosynthesis, Rats, Receptors; N-Methyl-D-Aspartate; drug effects, Transfer RNA Aminoacylation; drug effects, Valproic Acid; analysis/pharmacology
01 Pubblicazione su rivista::01a Articolo in rivista
Antidegenerative effects of Mg(2+)-valproate in cultured cerebellar neurons / Bruno, Valeria Maria Gloria; M. A., Sortino; U., Scapagnini; Nicoletti, Ferdinando; P. L., Canonico. - In: FUNCTIONAL NEUROLOGY. - ISSN 0393-5264. - 10:(1995), pp. 121-130.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/465949
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