Localized lesions with kainic acid (KA) and local infusion of GABAergic drugs were used to study the role of the nucleus fastigii (NF) in postural tonus. Unilateral axon-sparing KA lesions of NF resulted in ipsilateral limb extensor atonia and contralateral limb extensor hypertonus and abduction. This effect lasted for 3-8 days depending on the dose of KA. Lesions of sites adjacent to the NF failed to produce postural asymmetries. Local infusion of the GABA agonist muscimol (10-50 ng) in the NF produced a reversible postural asymmetry fenomenologically similar to that produced by KA lesions of NF. Infusion of agents blocking GABAergic transmission in the NF (bicuculline, picrotoxin) resulted in a postural asymmetry of inverted laterality in respect to that produced by muscimol. Bilateral KA lesions of NF or bilateral infusion of muscimol resulted in bilateral hyperextension-abduction of the limbs. Infusion of GABAergic drugs in areas adjacent to the NF failed to produce postural changes. The results are interpreted to indicate that the NF exerts a crossed inhibitory and a direct excitatory influence on limb postural tonus. © 1984.

Fastigial influences on postural tonus as studied by kainate lesions and by local infusion of GABAergic drugs in the rat / A., Imperato; Nicoletti, Ferdinando; M., Diana; U., Scapagnini; G. D., Chiara. - In: BRAIN RESEARCH. - ISSN 0006-8993. - 295:1(1984), pp. 51-63.

Fastigial influences on postural tonus as studied by kainate lesions and by local infusion of GABAergic drugs in the rat

NICOLETTI, Ferdinando;
1984

Abstract

Localized lesions with kainic acid (KA) and local infusion of GABAergic drugs were used to study the role of the nucleus fastigii (NF) in postural tonus. Unilateral axon-sparing KA lesions of NF resulted in ipsilateral limb extensor atonia and contralateral limb extensor hypertonus and abduction. This effect lasted for 3-8 days depending on the dose of KA. Lesions of sites adjacent to the NF failed to produce postural asymmetries. Local infusion of the GABA agonist muscimol (10-50 ng) in the NF produced a reversible postural asymmetry fenomenologically similar to that produced by KA lesions of NF. Infusion of agents blocking GABAergic transmission in the NF (bicuculline, picrotoxin) resulted in a postural asymmetry of inverted laterality in respect to that produced by muscimol. Bilateral KA lesions of NF or bilateral infusion of muscimol resulted in bilateral hyperextension-abduction of the limbs. Infusion of GABAergic drugs in areas adjacent to the NF failed to produce postural changes. The results are interpreted to indicate that the NF exerts a crossed inhibitory and a direct excitatory influence on limb postural tonus. © 1984.
1984
animals; bicuculline; cerebellar nuclei; diazepam; drug effects; drug effects/physiology; functional laterality; gamma-aminobutyric acid; inbred strains; kainic acid; male; motor activity; muscle tonus; pharmacology; physiology; picrotoxin; posture; pyrrolidines; rats; stereotaxic techniques; toxicity
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Fastigial influences on postural tonus as studied by kainate lesions and by local infusion of GABAergic drugs in the rat / A., Imperato; Nicoletti, Ferdinando; M., Diana; U., Scapagnini; G. D., Chiara. - In: BRAIN RESEARCH. - ISSN 0006-8993. - 295:1(1984), pp. 51-63.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/465884
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