Cerebellar granule cells in primary culture express receptors for excitatory amino acids. The activation of these receptors results in an increased uptake of Ca2+, however, the effects are different depending on the agonists used. Aspartate, NMDA and ibotenate are active only in depolarized conditions, whereas kainate and glutamate activate Ca2+ uptake independently from depolarization. The results indicate the presence of two receptor types: kainate recognition site coupled with voltage-independent Ca2+ channels and NMDA recognition site coupled with voltage-dependent Ca2+ channels. © 1985.
Different coupling of excitatory amino acid receptors with Ca2+ channels in primary cultures of cerebellar granule cells / J. T., Wroblewski; Nicoletti, Ferdinando; E., Costa. - In: NEUROPHARMACOLOGY. - ISSN 0028-3908. - 24:9(1985), pp. 919-921. [10.1016/0028-3908(85)90046-2]
Different coupling of excitatory amino acid receptors with Ca2+ channels in primary cultures of cerebellar granule cells
NICOLETTI, Ferdinando;
1985
Abstract
Cerebellar granule cells in primary culture express receptors for excitatory amino acids. The activation of these receptors results in an increased uptake of Ca2+, however, the effects are different depending on the agonists used. Aspartate, NMDA and ibotenate are active only in depolarized conditions, whereas kainate and glutamate activate Ca2+ uptake independently from depolarization. The results indicate the presence of two receptor types: kainate recognition site coupled with voltage-independent Ca2+ channels and NMDA recognition site coupled with voltage-dependent Ca2+ channels. © 1985.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.