Stimulation of inositol phospholipid hydrolysis by transmitter receptor agonists was studied in slices from the occipital, temporal and cerebellar cortex that were surgically removed from three patients during ablation of brain tumors. Norepinephrine and the muscarinic acetylcholine agonist carbamylcholine increased the content of [3H]inositol monophosphate (InsP) in all the regions examined, whereas the glutamate receptor agonist quisqualate was effective only in the cerebellar slices. These results provide evidence that neurotransmitter receptors are coupled to inositol phospholipid hydrolysis in human brain tissue.
Receptor-mediated stimulation of inositol phospholipid hydrolysis in human brain / Nicoletti, Ferdinando; P. L., Canonico; A., Favit; G., Nicoletti; V., Albanese. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - 160:(1989), pp. 299-301. [10.1016/0014-2999(89)90504-9]
Receptor-mediated stimulation of inositol phospholipid hydrolysis in human brain.
NICOLETTI, Ferdinando;
1989
Abstract
Stimulation of inositol phospholipid hydrolysis by transmitter receptor agonists was studied in slices from the occipital, temporal and cerebellar cortex that were surgically removed from three patients during ablation of brain tumors. Norepinephrine and the muscarinic acetylcholine agonist carbamylcholine increased the content of [3H]inositol monophosphate (InsP) in all the regions examined, whereas the glutamate receptor agonist quisqualate was effective only in the cerebellar slices. These results provide evidence that neurotransmitter receptors are coupled to inositol phospholipid hydrolysis in human brain tissue.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
