Inositol hexakisphosphate (InsP6) is thought to act as an intracellular signal molecule in the central nervous system. We report that InsP6 stimulates 45Ca2+ uptake in cultured anterior pituitary cells. This effect is concentration-dependent, is mimicked by inositol-pentakis phosphate (InsP5) but not by inositol-tetrakis phosphate (InsP4), is present after 2 min of incubation, is independent of extracellular Na+ and insensitive to nifedipine and verapamil. These results suggest that InsP6, a putative metabolite of the inositol cycle, may regulate transmembrane mechanism in the pituitary.

Inositol hexakisphosphate stimulates 45Ca2+ uptake in anterior pituitary cells in culture / M. A., Sortino; Nicoletti, Ferdinando; P. L., Canonico. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - 189:1(1990), pp. 115-118. [10.1016/0922-4106(90)90238-s]

Inositol hexakisphosphate stimulates 45Ca2+ uptake in anterior pituitary cells in culture.

NICOLETTI, Ferdinando;
1990

Abstract

Inositol hexakisphosphate (InsP6) is thought to act as an intracellular signal molecule in the central nervous system. We report that InsP6 stimulates 45Ca2+ uptake in cultured anterior pituitary cells. This effect is concentration-dependent, is mimicked by inositol-pentakis phosphate (InsP5) but not by inositol-tetrakis phosphate (InsP4), is present after 2 min of incubation, is independent of extracellular Na+ and insensitive to nifedipine and verapamil. These results suggest that InsP6, a putative metabolite of the inositol cycle, may regulate transmembrane mechanism in the pituitary.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/465839
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