Inositol hexakisphosphate (InsP6) stimulates 45Ca2+ influx in purified mitochondria from rat liver. The action of InsP6 is concentration-dependent, with an apparent EC50 value of 50 microM. Stimulation of 45Ca2+ influx may follow the interaction between InsP6 and specific membrane receptors. Accordingly, [3H]InsP6 binds to specific and saturable recognition sites in purified mitochondria. These results support the view that InsP6 acts as a signal molecule to regulate the intracellular homeostasis of Ca2+.
Inositol hexakisphosphate stimulates 45Ca2+ influx in purified mitochondria from rat liver / A., Copani; G., Raciti; Bruno, Valeria Maria Gloria; M. A., Sortino; Nicoletti, Ferdinando; P. L., Canonico; A., Cambria. - In: ITALIAN JOURNAL OF BIOCHEMISTRY. - ISSN 0021-2938. - 40:5(1991), pp. 289-294.
Inositol hexakisphosphate stimulates 45Ca2+ influx in purified mitochondria from rat liver.
BRUNO, Valeria Maria Gloria;NICOLETTI, Ferdinando;
1991
Abstract
Inositol hexakisphosphate (InsP6) stimulates 45Ca2+ influx in purified mitochondria from rat liver. The action of InsP6 is concentration-dependent, with an apparent EC50 value of 50 microM. Stimulation of 45Ca2+ influx may follow the interaction between InsP6 and specific membrane receptors. Accordingly, [3H]InsP6 binds to specific and saturable recognition sites in purified mitochondria. These results support the view that InsP6 acts as a signal molecule to regulate the intracellular homeostasis of Ca2+.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
