The effects of acute and chronic injections of haloperidol, sulpiride and apomorphine on serum prolactin (PRL) levels and medial basal hypothalamus (MBH) glutamic acid decarboxylase (GAD) activity were investigated in male rats. Parallel changes in PRL and GAD activity were observed in acutely treated animals. Conversely, a return to normal of the GAD activity associated with high plasma PRL levels was induced by chronic haloperidol and sulpiride treatment. Results are discussed in the light of the possible existence of a hypothetical PRL-gamma-aminobutyric acid (GABA) subsidiary feedback loop.
Possible role of prolactin in the modification of medial basal hypothalamic glutamic acid decarboxylase activity / A., Prato; G., Clementi; Nicoletti, Ferdinando; P. L., Canonico; F., Patti; D. F., Condorelli; R. M., Di; F., Drago. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - 71:1(1981), pp. 169-172.
Possible role of prolactin in the modification of medial basal hypothalamic glutamic acid decarboxylase activity.
NICOLETTI, Ferdinando;
1981
Abstract
The effects of acute and chronic injections of haloperidol, sulpiride and apomorphine on serum prolactin (PRL) levels and medial basal hypothalamus (MBH) glutamic acid decarboxylase (GAD) activity were investigated in male rats. Parallel changes in PRL and GAD activity were observed in acutely treated animals. Conversely, a return to normal of the GAD activity associated with high plasma PRL levels was induced by chronic haloperidol and sulpiride treatment. Results are discussed in the light of the possible existence of a hypothetical PRL-gamma-aminobutyric acid (GABA) subsidiary feedback loop.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.