The effects of different doses of the dopamine (DA) receptor agonist apomorphine on the activity of the gamma-aminobutyric acid (GABA)-synthesizing enzyme glutamic acid decarboxylase (GAD, EC 4.1.1.15) were investigated in rat substantia nigra in comparison with haloperidol and sulpiride, two DA receptor blocking agents. Results obtained show that low doses (10,35 microgram/kg, s.c.) of apomorphine induce a decrease in nigral GAD activity whilst an opposite effect is observed with the highest dose (1000 microgram/kg, s.c.). No significant change is observed following injection of the intermediate doses (100 and 500 microgram/kg, s.c.). Moreover, sulpiride at the dose used (2 mg/kg, i.p.) induces an increase in GAD activity whilst no effect follows systemic injection of the same dose of haloperidol. The results are discussed in light of recent neurochemical and behavioral data.

Effects of different doses of apomorphine on GAD activity in rat substantia nigra / D. F., Condorelli; G., Giammona; F., Patti; Nicoletti, Ferdinando; L., Rampello; A., Reggio; M., Matera; R. M., Di. - In: ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES. - ISSN 0392-0461. - 2:3(1981), pp. 303-306.

Effects of different doses of apomorphine on GAD activity in rat substantia nigra.

NICOLETTI, Ferdinando;
1981

Abstract

The effects of different doses of the dopamine (DA) receptor agonist apomorphine on the activity of the gamma-aminobutyric acid (GABA)-synthesizing enzyme glutamic acid decarboxylase (GAD, EC 4.1.1.15) were investigated in rat substantia nigra in comparison with haloperidol and sulpiride, two DA receptor blocking agents. Results obtained show that low doses (10,35 microgram/kg, s.c.) of apomorphine induce a decrease in nigral GAD activity whilst an opposite effect is observed with the highest dose (1000 microgram/kg, s.c.). No significant change is observed following injection of the intermediate doses (100 and 500 microgram/kg, s.c.). Moreover, sulpiride at the dose used (2 mg/kg, i.p.) induces an increase in GAD activity whilst no effect follows systemic injection of the same dose of haloperidol. The results are discussed in light of recent neurochemical and behavioral data.
1981
administration /&/ dosage/pharmacology; animals; apomorphine; carboxy-lyases; enzymology; glutamate decarboxylase; haloperidol; inbred strains; male; metabolism; pharmacology; rats; substantia nigra; sulpiride
01 Pubblicazione su rivista::01a Articolo in rivista
Effects of different doses of apomorphine on GAD activity in rat substantia nigra / D. F., Condorelli; G., Giammona; F., Patti; Nicoletti, Ferdinando; L., Rampello; A., Reggio; M., Matera; R. M., Di. - In: ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES. - ISSN 0392-0461. - 2:3(1981), pp. 303-306.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/465801
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