The authors have investigated the effects of acute or chronic injection of typical and atypical antidepressants on the activity of the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD, EC 4.1.1.15) in discrete brain regions. Very significant changes in GAD activity were observed only with sulpiride and nomifensine, two atypical antidepressants that selectively influence dopaminergic transmission and, in turn, prolactin secretion.

Effects of some typical and atypical antidepressants on GAD activity in various brain regions / L., Rampello; F., Patti; D. F., Condorelli; A., Reggio; A., Prato; P. L., Canonico; Nicoletti, Ferdinando. - In: L'ENCÉPHALE. - ISSN 0013-7006. - 8:1(1982), pp. 89-94.

Effects of some typical and atypical antidepressants on GAD activity in various brain regions

NICOLETTI, Ferdinando
1982

Abstract

The authors have investigated the effects of acute or chronic injection of typical and atypical antidepressants on the activity of the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD, EC 4.1.1.15) in discrete brain regions. Very significant changes in GAD activity were observed only with sulpiride and nomifensine, two atypical antidepressants that selectively influence dopaminergic transmission and, in turn, prolactin secretion.
1982
animals; antidepressive agents; blood; brain; carboxy-lyases; drug effects/enzymology; gamma-aminobutyric acid; glutamate decarboxylase; inbred strains; male; metabolism; pharmacology; prolactin; rats
01 Pubblicazione su rivista::01a Articolo in rivista
Effects of some typical and atypical antidepressants on GAD activity in various brain regions / L., Rampello; F., Patti; D. F., Condorelli; A., Reggio; A., Prato; P. L., Canonico; Nicoletti, Ferdinando. - In: L'ENCÉPHALE. - ISSN 0013-7006. - 8:1(1982), pp. 89-94.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/465796
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