The effects of i.v.c. injection of human and salmon calcitonin on biochemical and behavioral parameters related to the extrapyramidal motor system, were investigated in male rats. Calcitonin injection resulted in a potentiation of haloperidol-induced catalepsy and a partial prevention of apomorphine-induced hyperactivity. Moreover calcitonin induced a significant decrease in nigral GAD activity but no change in striatal DA and DOPAC concentration or GAD activity. The results are discussed in view of a primary action of calcitonin on the striatonigral GABAergic pathway mediating the DA-related behavioral messages of striatal origin. © 1982.
Effects of calcitonin on rat extrapyramidal motor system: behavioral and biochemical data / Nicoletti, Ferdinando; G., Clementi; F., Patti; P. L., Canonico; R. M., Di; M., Matera; G., Pennisi; L., Angelucci; U., Scapagnini. - In: BRAIN RESEARCH. - ISSN 0006-8993. - 250:2(1982), pp. 381-385.
Effects of calcitonin on rat extrapyramidal motor system: behavioral and biochemical data
NICOLETTI, Ferdinando;
1982
Abstract
The effects of i.v.c. injection of human and salmon calcitonin on biochemical and behavioral parameters related to the extrapyramidal motor system, were investigated in male rats. Calcitonin injection resulted in a potentiation of haloperidol-induced catalepsy and a partial prevention of apomorphine-induced hyperactivity. Moreover calcitonin induced a significant decrease in nigral GAD activity but no change in striatal DA and DOPAC concentration or GAD activity. The results are discussed in view of a primary action of calcitonin on the striatonigral GABAergic pathway mediating the DA-related behavioral messages of striatal origin. © 1982.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
