There is mounting evidence that several gonadal hormones may influence central nervous system. In particular, it has been found that estrogens display an antidopaminergic activity at the level of the extrapyramidal motor system. In this line we have investigated behavioral and biochemical parameters related to nigrostriatal DAergic function. Results obtained further indicate that estrogens display an antidopaminergic activity, by acting on nigrostriatal postsynaptic DAergic receptors. These results may suggest an antidyskinetic activity of estrogens.
Antidyskinetic properties of estrogens / F., Patti; G., Giammona; L., Rampello; A., Reggio; G., Gallitto; Nicoletti, Ferdinando. - In: BOLLETTINO DELLA SOCIETA' ITALIANA DI BIOLOGIA SPERIMENTALE. - ISSN 0037-8771. - 59:2(1983), pp. 213-219.
Antidyskinetic properties of estrogens.
NICOLETTI, Ferdinando
1983
Abstract
There is mounting evidence that several gonadal hormones may influence central nervous system. In particular, it has been found that estrogens display an antidopaminergic activity at the level of the extrapyramidal motor system. In this line we have investigated behavioral and biochemical parameters related to nigrostriatal DAergic function. Results obtained further indicate that estrogens display an antidopaminergic activity, by acting on nigrostriatal postsynaptic DAergic receptors. These results may suggest an antidyskinetic activity of estrogens.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
