We have studied the expression of the c-myc and c-abl oncogenes in two human leukemic K562 cell lines which do express hemoglobin genes retaining a differential rate of cell proliferation. Our data indicate that in hemin-induced K562(S) cells the expression of c-abl oncogene decreases and appears to be related to a decrease in the proliferation capacity rather than to the activation of differentiated functions. The K562(hC) cell line, which produces large amounts of Hb Gower 1 retaining an efficient rate of cell proliferation, expresses indeed the c-abl oncogene at high level. © 1984 Academic Press, Inc. All rights reserved.
Human leukemia K562 cells: Relationship between hemin-mediated erythroid induction, cell proliferation and expression of c-abl and c-myc oncogenes / R., Gambari; L., Del Senno; R., Piva; R., Barbieri; F., Amelotti; F., Bernardi; G., Marchetti; Citarella, Franca; Tripodi, Marco; A., Fantoni. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - STAMPA. - 125:1(1984), pp. 90-96.
Human leukemia K562 cells: Relationship between hemin-mediated erythroid induction, cell proliferation and expression of c-abl and c-myc oncogenes
CITARELLA, Franca;TRIPODI, Marco;
1984
Abstract
We have studied the expression of the c-myc and c-abl oncogenes in two human leukemic K562 cell lines which do express hemoglobin genes retaining a differential rate of cell proliferation. Our data indicate that in hemin-induced K562(S) cells the expression of c-abl oncogene decreases and appears to be related to a decrease in the proliferation capacity rather than to the activation of differentiated functions. The K562(hC) cell line, which produces large amounts of Hb Gower 1 retaining an efficient rate of cell proliferation, expresses indeed the c-abl oncogene at high level. © 1984 Academic Press, Inc. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
