To estimate the risk of HIV-1 transmission through breast-milk in children born to infected mothers, and to determine the relationship between duration of breast-feeding and risk. DESIGN AND METHODS: The study population included 168 breast-fed and 793 bottle-fed children born to seropositive mothers. All subjects were enrolled and followed-up in the Italian Register for HIV Infection in Children; HIV sero-status was defined in all children. Multivariate analysis was performed using a logistic regression model. Independent variables included biological factors (duration of breast-feeding, gestational age, clinical condition of mother at delivery, mode of delivery, birth-weight and sex). Year of birth and age when HIV infection was diagnosed were also considered in the analysis attempting to control for possible selection biases. RESULTS: Breast-feeding increased the risk of HIV-1 transmission. The estimated adjusted odds ratio for 1 day of breast- versus bottle-feeding was 1.19 (95% confidence interval, 1.10-1.28). The infection odds ratio of breast- versus bottle-feeding increased with the natural logarithm of the duration of practice. CONCLUSIONS: These results are the first to provide an appraisal of the additional risk of HIV-1 transmission associated with a seropositive mother breast-feeding her child. Biological significance of this route of transmission was supported by demonstration of a relationship between duration of breast-feeding and risk of HIV-1 transmission.
HIV-1 tramission throught breast-milk: appraisal of risk according to duration of feeding / De Martino, M.; Tovo, P. A.; Tozzi, A. E.; Pezzotti, P.; Galli, L.; Liviadotti, S.; Caselli, D.; Marchisio, P.; Giaquinto, G.; Fioredda, F.; Plebani, A.; Gabiano, C.; Zuccotti, V. G.; Conte, A.; Rizzi, M.; Mazzoni, P. L.; Ibba, P.; Ferrarris, G.; Benaglia, G.; Stegagno, M.; Masi, M.; Dallacasa, P.; Duse, Marzia; Rossi, G.; Sciotto, A.; Barbanera, M.; De Mattia, D.; Zaniboni, M.; Bezzi, T.; Campelli, A.; Ciccimarra, F.; Bassanetti, F.; Consolini, R.; Mazza, A.; Tarallo, L.; Altobelli, R.; Castaldo, A.; Fundarò, C.. - In: AIDS. - ISSN 0269-9370. - STAMPA. - (1992), pp. 991-997. [10.1097/00002030-199209000-00013]
HIV-1 tramission throught breast-milk: appraisal of risk according to duration of feeding
DUSE, MARZIA;
1992
Abstract
To estimate the risk of HIV-1 transmission through breast-milk in children born to infected mothers, and to determine the relationship between duration of breast-feeding and risk. DESIGN AND METHODS: The study population included 168 breast-fed and 793 bottle-fed children born to seropositive mothers. All subjects were enrolled and followed-up in the Italian Register for HIV Infection in Children; HIV sero-status was defined in all children. Multivariate analysis was performed using a logistic regression model. Independent variables included biological factors (duration of breast-feeding, gestational age, clinical condition of mother at delivery, mode of delivery, birth-weight and sex). Year of birth and age when HIV infection was diagnosed were also considered in the analysis attempting to control for possible selection biases. RESULTS: Breast-feeding increased the risk of HIV-1 transmission. The estimated adjusted odds ratio for 1 day of breast- versus bottle-feeding was 1.19 (95% confidence interval, 1.10-1.28). The infection odds ratio of breast- versus bottle-feeding increased with the natural logarithm of the duration of practice. CONCLUSIONS: These results are the first to provide an appraisal of the additional risk of HIV-1 transmission associated with a seropositive mother breast-feeding her child. Biological significance of this route of transmission was supported by demonstration of a relationship between duration of breast-feeding and risk of HIV-1 transmission.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
