Background: Serum and plasma vascular endothelial growth factor (VEGF) were measured in children with a solid tumor to investigate which provides better prognostic information. Patients and Methods: Seventeen patients under treatment were divided into two groups: without (n 8) and with (n 9) detectable disease at radiological assessment (groups I and 11). The control group consisted of 26 healthy children. VEGF was tested by enzyme-linked ELISA kit. Results: Serum VEGF concentrations in group II were statistically higher than those in group I (p<0.05) and those in controls (p=0.001), whereas the difference between group I and controls was not statistically significant (p=0.067). Plasma VEGF concentrations in group II were also statistically higher than those in group I (p<0.01) and those in controls (p=0.0001); the difference between group I and controls was also statistically significant (p=0.004). Conclusion: Plasma would be the more useful specimen for measurement of circulating VEGF in cancer childhood.

Circulating Vascular Endothelial Growth Factor in Childhood Solid Tumors: Plasma and Serum Measurements / Schiavetti, Amalia; Ingrosso, A.; Antenucci, A.; Federici, T.; Megaro, Giacomina; Laura, De Luca; Conti, L.. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - STAMPA. - 32:8(2012), pp. 3565-3569.

Circulating Vascular Endothelial Growth Factor in Childhood Solid Tumors: Plasma and Serum Measurements

SCHIAVETTI, Amalia;MEGARO, GIACOMINA;
2012

Abstract

Background: Serum and plasma vascular endothelial growth factor (VEGF) were measured in children with a solid tumor to investigate which provides better prognostic information. Patients and Methods: Seventeen patients under treatment were divided into two groups: without (n 8) and with (n 9) detectable disease at radiological assessment (groups I and 11). The control group consisted of 26 healthy children. VEGF was tested by enzyme-linked ELISA kit. Results: Serum VEGF concentrations in group II were statistically higher than those in group I (p<0.05) and those in controls (p=0.001), whereas the difference between group I and controls was not statistically significant (p=0.067). Plasma VEGF concentrations in group II were also statistically higher than those in group I (p<0.01) and those in controls (p=0.0001); the difference between group I and controls was also statistically significant (p=0.004). Conclusion: Plasma would be the more useful specimen for measurement of circulating VEGF in cancer childhood.
2012
plasma; vascular endothelial growth factor; childhood tumor; serum
01 Pubblicazione su rivista::01a Articolo in rivista
Circulating Vascular Endothelial Growth Factor in Childhood Solid Tumors: Plasma and Serum Measurements / Schiavetti, Amalia; Ingrosso, A.; Antenucci, A.; Federici, T.; Megaro, Giacomina; Laura, De Luca; Conti, L.. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - STAMPA. - 32:8(2012), pp. 3565-3569.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/464277
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