Nausea and vomiting are common gastrointestinal symptoms following opioid administration, for either chronic or acute pain management. As a consequence, patients' dissatisfaction has a negative impact on treatment efficacy. A number of mechanisms have been identified, involving both central and peripheral sites. This article will review the pathophysiology of opioid-induced nausea and vomiting and the various pharmacological treatments currently available for its management. Preventive strategies and therapeutic approaches are evaluated in the perioperative setting and in chronic pain. Newer drugs include second generation serotonin receptor antagonists (palonosetron) and neurokinin-1 (NK-1) antagonists (aprepitant). © 2012 Bentham Science Publishers.
Non-analgesic effects of opioids: Opioid-induced nausea and vomiting: Mechanisms and strategies for their limitation / Coluzzi, Flaminia; Alessandra, Rocco; Mandatori, Ilenia; Mattia, Consalvo. - In: CURRENT PHARMACEUTICAL DESIGN. - ISSN 1381-6128. - STAMPA. - 18:37(2012), pp. 6043-6052. [10.2174/138161212803582540]
Non-analgesic effects of opioids: Opioid-induced nausea and vomiting: Mechanisms and strategies for their limitation
COLUZZI, FLAMINIA;MANDATORI, ILENIA;MATTIA, Consalvo
2012
Abstract
Nausea and vomiting are common gastrointestinal symptoms following opioid administration, for either chronic or acute pain management. As a consequence, patients' dissatisfaction has a negative impact on treatment efficacy. A number of mechanisms have been identified, involving both central and peripheral sites. This article will review the pathophysiology of opioid-induced nausea and vomiting and the various pharmacological treatments currently available for its management. Preventive strategies and therapeutic approaches are evaluated in the perioperative setting and in chronic pain. Newer drugs include second generation serotonin receptor antagonists (palonosetron) and neurokinin-1 (NK-1) antagonists (aprepitant). © 2012 Bentham Science Publishers.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.